R&D

Drugs

01
AL101-AOB

  • Obesity has emerged as a major public health problem due to its high prevalence and association with increased risk towards the development of a metabolic syndrome

  • The incidence of lifestyle diseases like hypertension, diabetes, hyperlipidemia, various heart diseases and stroke etc. is much higher for people who have a visceral type of abdominal fatness, even if they have the same Body Mass Index (BMI) like others

  • Subcutaneous fat and visceral fat are metabolically different

  • Visceral fat contributes to the pathogenesis of the underlying metabolic syndrome

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복부비만의 문제

AL101-AOB

Background of
Development

  • Most of the anti-obesity drugs focus on weight loss

  • Obesity-related metabolic syndrome is linked to visceral fat

  • Safety is the most important issue to be considered against side effects

  • Angiogenesis inhibitors can inhibit the growth of visceral fat safely
Summary of
Product

  • AL101-AOB inhibits angiogenesis targeting VEGF, bFGF and MMP

  • AL101-AOB is a botanical drug prepared by activity-guided fractionation from Melissa

  • It is standardized by two reference compounds

  • Nonclinical studies were completed in Australia and Korea

  • Visceral fat was confirmed to be reduced during the phase ll human trial through CT analysis

Reduction of visceral fat by 15% after a 12-week treatment of AL101-AOB (CT scan)

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02
AL101-AMD

Background of
Development

  • Rapid increase in the number of patients worldwide due to lifestyle changes

  • Limitations of current therapies: intravitreal injections, psychological burden, high treatment costs, inflammation, and other adverse effects
Development Objective

  • Develop an oral therapy suitable for long-term treatment

  • Expand the indications of ALS-L1023


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Summary of
Product

  • Oral efficacy demonstrated in a choroidal neovascularization animal model

  • Phase 2 completed: visual-acuity improvement confirmed in wet AMD; licensed to Hanlim Pharm / Sangmyung Innovation

  • Phase 3 development ongoing since 2025; global out-licensing underway

Competitors

Classification
Lucentis
Eylea
Vabysmo
AL101-AMD

Company

Genentech

Regeneron

Roche

AngioLab

Active ingredient

Ranibizumab

Aflibercept

Faricimab-svoa

ALS-L1023

Mechanism

Anti-VEGF antibody fragment

Fusion Protein of VEGFR

VEGF-A and Angiopoietin
2 inhibition

VEGF, bFGF, PDGF, MMPs inhibition

Side effect

Increased risk of stroke,
Vision change,
Pain in the eyes,
Red eye

Increased risk of stroke,
Vision change,
Pain in the eyes,
Red eye

Conjunctival hemorrhage,
Cataracts,
Bloody eye

No adverse effects

Remarks

FDA Approved(2006)
Direct injection into the eye
(Every 4 weeks)

FDA Approved(2011)
Direct injection into the eye
(Every 8 weeks)

FDA Approved(2022)
Direct injection into the eye
(Every 16 weeks)

Orally administered

03
AL101-MASH

Background of
Development

  • MASH is the most common chronic liver disease globally and is the fastest growing reason for liver transplants

  • Despite a major unmet need for drugs during the treatment of MASH, there are still no approved MASH drug in the market
Development Objective

  • Suppress lipid accumulation in the liver by inhibiting angiogenesis

  • Protect liver cells from injury by inhibiting the activation of IL-6 and NO through an anti-inflammatory mechanism

  • Improve fibrosis of liver cells through the regulation of produced collagen matrix by inhibiting MMP activity


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Summary of
Product

  • AL101-MASH regulates and cures the etiology of MASH directly through the suppression of fat accumulation, anti-inflammatory activity, and prevention of fibrosis by inhibiting the MMP

  • AL101-MASH Phase 2a clinical trial completed

04
AL102-PDT

Background of
Development

  • Rapid increase in periodontal disease and limitations of existing gum-disease treatments
Development Objective

  • Develop a treatment for periodontal disease

  • Prevent tooth loss by inhibiting MMP-2, MMP-9, and MMP-13, which degrade type I collagen in the periodontal ligament and alveolar bone


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Summary of
Product

  • Botanical drug that inhibits MMP enzymes

  • Superior efficacy to doxycycline and Insadol in a canine periodontitis model

  • Phase 2 clinical trial completed

05
AL101-OME

Background of
Development

  • Otitis Media with Effusion (OME) is the most common cause of hearing loss

  • No drug is available as of now
Development Objective

  • Angiogenesis inhibitors play a role in reducing the amount of effusion

  • VEGF and MMP, the important factors of OME, are effectively inhibited


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Summary of Product

  • Orally administered and safe, when compared with currently implemented treatments such as eardrum incision or ventilation system insertion

  • Showed efficacy in an animal disease model

  • AL101-OME Phase 2a clinical trial completed

06
AL101-ROSA

Background of
Development

  • Rosacea is a common skin condition that causes flushing or long-term redness on face. There's no cure for rosacea.
Development Objective

  • Angiogenesis inhibitors play a role in improving the disease condition

  • VEGF and MMP activities are inhibited

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Summary of Product

  • Showed efficacy in an animal disease model

07
AL101-PSO

Background of
Development

  • Number of patients with Psoriasis accounts for 2~3% of the total population and has been increasing sharply

  • Antibody drugs which are quite expensive dominate the market today
Development Objective

  • Angiogenesis inhibitors play a role in improving the disease condition

  • VEGF and MMP activities are inhibited
Summary of Product

  • Orally administered and safe, and has price competitiveness

  • Showed efficacy in an animal disease model

08
AL201-AB

Background of
Development

  • Current antibody drugs for wet AMD only target VEGF, which results in developing resistance in patients
Development Objective

  • New dual inhibitor which targets not only VEGFR1 but also VEGFR2
Summary of Product

  • Can be used for patients with resistance for the current antibody drugs as single-dose or combination therapy

09
SPACE Peptide
Skin-Penetrating And Cell-Entering Peptide

Background of
Development

  • Growing demand for high-performance, high-value-added ingredients such as peptides, growth factors, and protein-derived materials

  • Need for more efficient skin delivery of high-molecular-weight ingredients with poor stratum-corneum permeability
Development Objective

  • Develop highly effective anti-wrinkle ingredients through a platform that overcomes the delivery limitations of macromolecular and protein-based actives

  • Establish a non-invasive peptide-based transdermal delivery platform that preserves biological activity

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Summary of Product

  • Next-generation platform for delivery through skin and into cells, hair, and ocular tissues

  • Overcomes the membrane-level limitations of conventional cell-penetrating peptides

  • Efficacy, permeability, and safety validated in multiple animal models

  • Commercialization potential across cosmetics, pharmaceuticals, ophthalmology, and alopecia treatment

SPACE Peptide Mechanism of Action

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